RNA Details
Disease Name
endomyocardial fibrosis
Tissue
heart
RNA Symbol
mir-125b-1
RNA ID
RNA Type
miRNA
Alteration Pattern
up regulation
Species
mus musculus
Detection Methods
MTT ASSAY; PCR; Masson's trichrome staining; immunohistochemistry; etc.
Target
APELIN
Pathway
TGF-BETA SIGNALING PATHWAY
PubMed ID
Title
MiR-125b is Critical for Fibroblast-to-Myofibroblast Transition and Cardiac Fibrosis
Year
2016
Function
miR-125b is necessary and sufficient for the induction of fibroblast-to-myofibroblast transition by functionally targeting Apelin and inhibits p53 to induce fibroblast proliferation.